Michael Downes Selected Research

4- (2,6- dimethyl- 4- (4- trifluoromethoxyphenyl)piperazine- 1- sulfonyl)indan- 2- carboxylic acid

5/2012

Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist.

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Michael Downes Research Topics

Disease

21	Inflammation (Inflammations) 01/2022 - 03/2008
17	Neoplasms (Cancer) 11/2022 - 03/2008
13	Obesity 01/2022 - 06/2009
11	Fibrosis (Cirrhosis) 01/2021 - 01/2012
9	Insulin Resistance 01/2022 - 03/2008
8	Pancreatic Neoplasms (Pancreatic Cancer) 11/2022 - 09/2014
8	Type 2 Diabetes Mellitus (MODY) 01/2022 - 12/2009
6	Metabolic Diseases (Metabolic Disease) 01/2022 - 02/2011
6	Cholestasis 02/2015 - 02/2005
5	Non-alcoholic Fatty Liver Disease 01/2019 - 02/2016
4	Fatty Liver 01/2021 - 09/2014
4	Liver Diseases (Liver Disease) 01/2018 - 02/2005
4	Liver Cirrhosis (Hepatic Cirrhosis) 08/2016 - 05/2012
4	Atherosclerosis 03/2011 - 03/2008
3	Autoimmune Diseases (Autoimmune Disease) 10/2019 - 03/2011
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 07/2015
2	Weight Loss (Weight Reduction) 11/2021 - 03/2013
2	Colorectal Neoplasms (Colorectal Cancer) 01/2019 - 11/2015
2	Hyperglycemia 01/2019 - 05/2011
2	Carcinogenesis 01/2019 - 01/2017
2	Adenocarcinoma 10/2017 - 04/2017
2	Weight Gain 02/2015 - 09/2014
2	Pancreatitis 01/2015 - 09/2014
1	Atopic Dermatitis (Atopic Eczema) 01/2022
1	Immune System Diseases (Immune Disorders) 01/2022
1	Chronic Pancreatitis 01/2022
1	COVID-19 03/2021
1	Cystic Fibrosis (Mucoviscidosis) 01/2020
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2020

Drug/Important Bio-Agent (IBA)

10	Glucose (Dextrose)FDA LinkGeneric 11/2022 - 09/2014
10	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 10/2019 - 03/2008
9	Bile Acids and Salts (Bile Acids)IBA 01/2020 - 02/2005
9	LigandsIBA 10/2018 - 02/2005
6	Proteins (Proteins, Gene)FDA Link 11/2021 - 01/2017
6	Pharmaceutical PreparationsIBA 01/2019 - 12/2005
6	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2018 - 04/2013
6	Insulin (Novolin)FDA Link 01/2017 - 05/2013
4	Hormones (Hormone)IBA 01/2022 - 03/2008
4	GlucocorticoidsIBA 01/2019 - 10/2011
4	CholesterolIBA 02/2015 - 02/2005
3	EnzymesIBA 01/2022 - 09/2013
3	CytokinesIBA 01/2022 - 10/2011
3	LipidsIBA 01/2021 - 02/2005
3	DNA (Deoxyribonucleic Acid)IBA 11/2020 - 04/2017
3	Thyroid Hormone Receptors (Thyroid Hormone Receptor)IBA 10/2018 - 02/2011
3	Transcription Factors (Transcription Factor)IBA 10/2018 - 10/2011
3	Pregnane X ReceptorIBA 10/2018 - 07/2006
3	Fibroblast Growth Factor 1 (FGF-1)IBA 10/2017 - 09/2014
3	amlexanox (Aphthasol)FDA Link 07/2017 - 03/2013
3	ThiazolidinedionesIBA 02/2016 - 12/2009
3	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 02/2016 - 05/2012
3	Vitamin D FDA LinkGeneric 11/2015 - 09/2014
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 05/2012
2	LeptinIBA 01/2022 - 02/2016
2	GlycogenIBA 11/2021 - 09/2014
2	ChromatinIBA 11/2020 - 10/2020
2	Messenger RNA (mRNA)IBA 11/2020 - 10/2018
2	MethyltransferasesIBA 10/2020 - 04/2017
2	fibroblast growth factor 21IBA 01/2019 - 07/2015
2	PPAR gammaIBA 10/2018 - 12/2009
2	Constitutive Androstane ReceptorIBA 10/2018 - 09/2013
2	Ethanol (Ethyl Alcohol)IBA 01/2018 - 12/2005
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 11/2017 - 10/2017
2	Phosphotransferases (Kinase)IBA 07/2017 - 03/2013
2	Biological ProductsIBA 11/2015 - 09/2013
2	calcipotriene (calcipotriol)FDA LinkGeneric 11/2015 - 09/2014
2	CorticosteroneIBA 05/2013 - 12/2011
2	Orphan Nuclear ReceptorsIBA 05/2013 - 12/2012
2	RetinoidsIBA 10/2011 - 02/2011
2	Co-Repressor ProteinsIBA 02/2011 - 03/2008
2	PPAR deltaIBA 03/2008 - 03/2008
1	NAD (NADH)IBA 11/2022
1	KetonesIBA 11/2022
1	Tricarboxylic AcidsIBA 11/2022
1	CatecholaminesIBA 01/2022
1	NucleotidesIBA 01/2022
1	Adrenergic Receptors (Adrenergic Receptor)IBA 11/2021
1	prolyl T RNA synthetaseIBA 03/2021
1	Proline (L-Proline)FDA Link 03/2021
1	halofuginoneIBA 03/2021
1	Polysaccharides (Glycans)IBA 01/2021
1	Scavenger Receptors (Scavenger Receptor)IBA 01/2021
1	Galactoside 2-alpha-L-fucosyltransferase (Fucosyltransferase 2)IBA 01/2021
1	Proton Pump InhibitorsIBA 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2021
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2021
1	CollagenIBA 11/2020
1	RNA Polymerase II (RNA Polymerase B)IBA 11/2020
1	triptolideIBA 11/2020
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 11/2020
1	Serum AlbuminIBA 11/2020
1	TransposasesIBA 10/2020
1	Lysine (L-Lysine)FDA Link 10/2020

Therapy/Procedure

16	Therapeutics 11/2022 - 03/2008
3	Drug Therapy (Chemotherapy) 11/2022 - 09/2014
2	Ligation 05/2012 - 02/2005
1	Ketogenic Diet 11/2022
1	Immunotherapy 01/2022
1	Biological Therapy 01/2022
1	Precision Medicine 01/2022